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It can be used as a curative measure, both by itself and in combination with other treatments such as radiotherapy or surgery (both pre and post), as well as for palliative treatment

In particular, mechanism-based inactivation (MBI) often involves metabolic bioactivation of natural products by drug metabolizing enzyme to an electrophilic reactive intermediate, which covalently modifies an active site amino acid residue and/or coordinates to the heme prosthetic group, and leads to quasi-irreversible or irreversible inactivation (Zhang et al., 2020b)

This glutathione-mediated antioxidant pathway is responsible for reducing cystine into free cysteine by the glutathione [GSH/GSSG] redox coupling [25]

Selective induction of endogenous NQO1 was seen in metabolically relevant target tissues of Keap1 -KO mice including skeletal muscle, liver, and WAT while expression of other Nrf2 targets such as the antioxidants GCLC, HO-1 and SOD2 was minimally impacted

Finally, we highlight potential treatments that target cerebral metabolism, such as nutraceuticals, ketone bodies and dietary interventions